3,4-dihydroxycinnamic acid, caffeic acid, caffeic acid, (E)-isomer, caffeic acid, (Z)-isomer, caffeic acid, monosodium salt, cis-caffeic acid, sodium caffeate, trans-caffeic acid
| Name | Caffeic acid | ||
| PubChem CID | 689043 | ||
| Molecular Weight | 180.16g/mol | ||
| Synonyms |
3,4-dihydroxycinnamic acid, caffeic acid, caffeic acid, (E)-isomer, caffeic acid, (Z)-isomer, caffeic acid, monosodium salt, cis-caffeic acid, sodium caffeate, trans-caffeic acid |
||
| Formula | C₉H₈O₄ | ||
| SMILES | C1=CC(=C(C=C1C=CC(=O)O)O)O | ||
| InChI | 1S/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2+ | ||
| InChIKey | QAIPRVGONGVQAS-DUXPYHPUSA-N | ||
| CAS Number | 331-39-5 | ||
| ChEMBL ID | CHEMBL145 | ||
| ChEBI ID | CHEBI:36281 | ||
| Drug Bank ID | DB01880 | ||
| KEGG ID | C01197 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
|
Download
2D
MOL
3D
MOL
|
|
| Chineses Pinyin | XieCao | ||
| Use Part | Root, Rhizome | ||
| Habitat | Shaanxi, GanSu, QingHai, XinJiang, SiChuan, HeBei, HeNan, ShanDong, ShanXi, TaiWan, HuBei | ||
| Flavor | Pungent, Sweet | ||
| Meridian Tropism | Heart, Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Dipsacales
-->Family: Caprifoliaceae
-->Genus: Valeriana
-->Species: Valeriana officinalis
|
||
| Chineses Pinyin | ZhiZhuXiang | ||
| Use Part | Rhizome | ||
| Habitat | Shaanxi, HeNan, HuBei, HuNan, SiChuan, GuiZhou, YunNan, XiZang | ||
| Flavor | Mildly bitter, Pungent | ||
| Meridian Tropism | Heart, Spleen, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Dipsacales
-->Family: Caprifoliaceae
-->Genus: Valeriana
-->Species: Valeriana jatamansi
|
||
| Chineses Pinyin | BoHe | ||
| Use Part | Aerial Parts | ||
| Habitat | JiangSu | ||
| Flavor | Pungent | ||
| Meridian Tropism | Lung, Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Mentha
-->Species: Mentha haplocalyx
|
||
| Chineses Pinyin | ZiSuGeng | ||
| Use Part | Stem | ||
| Habitat | HuBei, JiangSu, HeNan, SiChuan, GuangXi, ShanDong, GuangDong, ZheJiang, HeBei, ShanXi | ||
| Flavor | Pungent | ||
| Meridian Tropism | Lung, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Perilla
-->Species: Perilla frutescens
|
||
| Chineses Pinyin | SiJiQing | ||
| Use Part | Leaf | ||
| Habitat | HuNan, JiangXi, ZheJiang, FuJian, GuangDong, GuiZhou, YunNan, HaiNan, XiZang, TaiWan | ||
| Flavor | Bitter, Astringent | ||
| Meridian Tropism | Lung, Large intestine, Bladder | ||
| Chineses Pinyin | DuZhongYe | ||
| Use Part | Leaf | ||
| Habitat | Shaanxi, GanSu, HeNan, HuBei, HuNan, SiChuan, YunNan, GuiZhou, ZheJiang | ||
| Flavor | Mildly pungent | ||
| Meridian Tropism | Liver, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Garryales
-->Family: Eucommiaceae
-->Genus: Eucommia
-->Species: Eucommia ulmoides
|
||
| Chineses Pinyin | GuYa | ||
| Use Part | Mature Fruit Of Millet Is Formed By Germination And Drying | ||
| Habitat | China | ||
| Flavor | Sweet | ||
| Meridian Tropism | Spleen, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Poales
-->Family: Poaceae
-->Genus: Setaria
-->Species: Setaria italica
|
||
| Chineses Pinyin | ShengDiHongJingTian | ||
| Use Part | Whole Grass | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, GanSu, QingHai, NingXia, XinJiang, SiChuan, GuiZhou, YunNan, XiZang, ChongQing, NingXia, GanSu, QingHai, SiChuan, XiZang | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Saxifragales
-->Family: Crassulaceae
-->Genus: Rhodiola
-->Species: Rhodiola sacra
|
||
| Chineses Pinyin | PuGongYing | ||
| Use Part | Whole Grass | ||
| Habitat | China | ||
| Flavor | Bitter, Sweet | ||
| Meridian Tropism | Liver, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asterales
-->Family: Asteraceae
-->Genus: Taraxacum
-->Species: Taraxacum mongolicum
|
||
| Chineses Pinyin | YiZhiHuangHua | ||
| Use Part | Whole Herb | ||
| Habitat | JiangSu, ZheJiang, JiangXi, HuNan, HuBei, GuangXi, GuangDong, SiChuan, GuiZhou | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Lung, Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asterales
-->Family: Asteraceae
-->Genus: Solidago
-->Species: Solidago decurrens
|
||
| Chineses Pinyin | BianXu | ||
| Use Part | Aerial Parts | ||
| Habitat | China | ||
| Flavor | Bitter | ||
| Meridian Tropism | Bladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Caryophyllales
-->Family: Polygonaceae
-->Genus: Polygonum
-->Species: Polygonum aviculare
|
||
| Chineses Pinyin | MaHuang | ||
| Use Part | Herbaceous Twigs | ||
| Habitat | LiaoNing, JiLin, NeiMengGu, HeBei, ShanXi, HeNan, GanSu, QingHai, NingXia, XinJiang, Shaanxi | ||
| Flavor | Pungent, Mildly bitter | ||
| Meridian Tropism | Lung, Bladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Ephedrales
-->Family: Ephedraceae
-->Genus: Ephedra
-->Species: Ephedra sinica
|
||
| Chineses Pinyin | MiHouTao | ||
| Use Part | Fruit | ||
| Habitat | HeNan, HuNan, HuBei, GuangDong, GuangXi, HaiNan, Shaanxi, SiChuan, JiangSu, AnHui, ZheJiang, JiangXi, FuJian, GuiZhou, YunNan | ||
| Flavor | Sour, Sweet | ||
| Meridian Tropism | Stomach, Liver | ||
| Chineses Pinyin | MuZei | ||
| Use Part | Aerial Parts | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, HeBei, Shaanxi, GanSu, XinJiang, SiChuan | ||
| Flavor | Sweet, Bitter | ||
| Meridian Tropism | Lung, Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Equisetales
-->Family: Equisetaceae
-->Genus: Equisetum
-->Species: Equisetum hyemale
|
||
| Chineses Pinyin | FuPenZi | ||
| Use Part | Aggregate Fruit | ||
| Habitat | AnHui, JiangSu, ZheJiang | ||
| Flavor | Sweet, Sour | ||
| Meridian Tropism | Liver, Kidney, Bladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Rosales
-->Family: Rosaceae
-->Genus: Rubus
-->Species: Rubus chingii
|
||
| Chineses Pinyin | ShanZhaYe | ||
| Use Part | Leaf | ||
| Habitat | ShanDong, HeNan, HeBei, LiaoNing | ||
| Flavor | Sour | ||
| Meridian Tropism | Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Rosales
-->Family: Rosaceae
-->Genus: Crataegus
-->Species: Crataegus pinnatifida
|
||
| Chineses Pinyin | JinYinHua | ||
| Use Part | Flower Bud | ||
| Habitat | JiangSu, ZheJiang, AnHui, FuJian, JiangXi, ShanDong, ShangHai, HeNan, HuNan, HuBei, GuangDong, GuangXi, HaiNan, SiChuan, GuiZhou, YunNan, XiZang, ChongQing, HeBei, ShanXi, LiaoNing, Shaanxi, GanSu | ||
| Flavor | Sweet | ||
| Meridian Tropism | Lung, Heart, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Dipsacales
-->Family: Caprifoliaceae
-->Genus: Lonicera
-->Species: Lonicera japonica
|
||
| Chineses Pinyin | BeiShaShen | ||
| Use Part | Root | ||
| Habitat | LiaoNing, HeBei, ShanDong | ||
| Flavor | Sweet, Mildly bitter | ||
| Meridian Tropism | Lung, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Apiaceae
-->Genus: Glehnia
-->Species: Glehnia littoralis
|
||
| Chineses Pinyin | ChuanXiong | ||
| Use Part | Rhizome | ||
| Habitat | SiChuan | ||
| Flavor | Pungent | ||
| Meridian Tropism | Liver, Gallbladder, Pericardium | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Apiaceae
-->Genus: Ligusticum
-->Species: Ligusticum sinense
|
||
| Chineses Pinyin | ZiCao | ||
| Use Part | Root | ||
| Habitat | YunNan, XiZang, SiChuan, GuiZhou | ||
| Flavor | Sweet, Salty | ||
| Meridian Tropism | Heart, Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Boraginales
-->Family: Boraginaceae
-->Genus: Arnebia
-->Species: Arnebia euchroma
|
||
| Chineses Pinyin | KaFei | ||
| Use Part | Seed | ||
| Habitat | GuangDong, GuangXi, FuJian, TaiWan, HaiNan, SiChuan, GuiZhou, YunNan | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Gentianales
-->Family: Rubiaceae
-->Genus: Coffea
-->Species: Coffea
|
||
| Pair Name | Caffeic acid, Paclitaxel | |||
| Partner Name | Paclitaxel | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Up-regulation | Expression | BID | hsa637 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Up-regulation | Expression | CASP9 | hsa842 | |
| Up-regulation | Cleavage | JUN | hsa3725 | |
| Up-regulation | Phosphorylation | MAPK1 | hsa5594 | |
| Up-regulation | Phosphorylation | MAPK3 | hsa5595 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| In Vitro Model | NCI-H1299 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0060 |
| In Vivo Model | Xenograft models were established by subcutaneous injections of H1299 cells (5×10⁶) suspended in Matrigel, and the behavior and growth of tumors among the mice were observed daily. | |||
| Result | Our results indicated that CA inhibited NSCLC H1299 cell growth by inducing apoptosis and CA and PTX combined produced a synergistic anti-cancer effect in H1299 cells. | |||
